Fgf
Ligands - "canonical" - Heparin/heparansulhate - intracelullar - Alternative splicing - Role in tissue preference
Signal transduction - RTK - GRB2 - SH2 - RAS/RAF/MEK/MAPK - And PI3K - after phosphorylation can terminate fgfr signal - negativ fb - FRS2a scaffold - Also STAT and PLC/Ca/pkc
KOs - Ligands - more of them and more specific -> les ssevere phenotype - Receptors - ยจ - FGFR3 - Not embryonically lethal but bone growth dysregulation - isoforms - different phenotype - fgfr3c - cartilage suppression -> KOs cause ocergrowth of nboen
Disorders - Achondroplasia - most common form of dwarfism - 97 % dominant missense - bone growtt - end -> reserve chondrocytes - proliterative chondrocytes - -> differentiation: -> osteoblasts -